홍성철 교수

홍성철 교수

교육

1994
서울대학교 물리학 학사
1996
서울대학교 물리학 석사
2000
서울대학교 물리학 박사
2000 ~ 2001
서울대학교 박사후연구원
2002 ~ 2006
일리노이대학교(UIUC) 박사후연구원
2006 ~ 현재
서울대 물리천문학부 교수

주요 연구분야

단일분자 생물물리학

대표 연구성과

  1. "DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA", PNAS (2012).
  2. "Hidden complexity in the isomerization dynamics of Holliday junctions", Nat Chem. (2012).
  3. "Kinetic mechanism for viral dsRNA length discrimination by MDA5 filaments", PNAS (2012).
  4. "A single-molecule dissection of ligand binding to a protein with intrinsic dynamics", Nat Chem Biol. (2013).
  5. "Maximizing information content of single-molecule FRET experiments: multi-color FRET and FRET combined with force or torque", Chem Soc Rev. (2014).
  6. "Sub-diffraction limit imaging of inorganic nanowire networks interfacing cells", Small. (2014).
  7. "Dynamic anchoring of the 3'-end of the guide strand controls the target dissociation of Argonaute-guide complex", J Am Chem Soc. (2013).
  8. "An optical trap combined with three-color FRET", J Am Chem Soc. (2013).
  9. "Protein conformational dynamics dictate the binding affinity for a ligand", Nat Commun. (2014).
  10. "Functional Anatomy of the Human Microprocessor", Cell. (2015).
  11. "Human Argonaute 2 Has Diverse Reaction Pathways on Target RNAs" Mol Cell. (2015).
  12. "AUF1 promotes let-7b loading on Argonaute 2", Genes Dev. (2015).
  13. "Structure of Human DROSHA", Cell (2016).
  14. "AUF1 facilitates microRNA-mediated gene silencing", Nucleic Acids Research (2017).
  15. "NAP1L1 accelerates activation and decreases pausing to enhance nucleosome remodeling by CSB", Nucleic Acids Research (2017).